Open AccessAntidepressant-like activity of flunarizine in modified tail suspension test in rats
Author(s) -
Vinod Shinde,
Radha Yegnanarayan,
Priyank Shah,
Ankush Gupta,
Prachi Pophale
Publication year - 2015
Publication title -
north american journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2250-1541
pISSN - 1947-2714
DOI - 10.4103/1947-2714.153921
Subject(s) - flunarizine , behavioural despair test , tail suspension test , saline , medicine , fluoxetine , pharmacology , analysis of variance , antidepressant , tricyclic antidepressant , anesthesia , serotonin , calcium , hippocampus , receptor
Flunarizine, a Ca(2+) channel blocker, crosses blood brain barrier (BBB), antagonizes calcium influx and interferes with neurotransmitter system. Flunarizine 20 mg/kg exhibited significant antidepressant activity in our previous study using forced swim test (FST) in mice, which was contradictory to the findings of other authors. Hence, the present study was designed to strengthen the results of our previous study, using the modified tail suspension test (TST) in rats.