Open AccessDrug-Induced gingival overgrowth: The genetic dimension
Author(s) -
Noronha Shyam Curtis Charles,
Rahul B. Chavan,
Ninad Moon,
Srinivas Nalla,
Jaydeepchandra Mali,
Anchal Prajapati
Publication year - 2014
Publication title -
north american journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2250-1541
pISSN - 1947-2714
DOI - 10.4103/1947-2714.141651
Subject(s) - cyp2c9 , genotyping , medicine , cyp2c19 , genotype , phenytoin , gingival enlargement , population , allele , pharmacogenomics , genetics , pharmacology , epilepsy , biology , gene , pathology , environmental health , psychiatry
Currently, the etiology of drug-induced gingival overgrowth is not entirely understood but is clearly multifactorial. Phenytoin, one of the common drugs implicated in gingival enlargement, is metabolized mainly by cytochrome P450 (CYP)2C9 and partly by CYP2C19. The CYP2C9 and CYP2C19 genes are polymorphically expressed and most of the variants result in decreased metabolism of the respective substrates.