Open AccessAllele frequencies of the epidermal growth factor receptors polymorphism r521k in colorectal cancer patients and healthy subjects indicate a risk-reducing effect of k521 in Syrian population
Author(s) -
Ola Haj Mustafa,
Abdul Rezzak Hamzeh,
Lina Ghabreau,
Nizar Akil,
Ala-Eddin Al-Moustafa,
Amal Alachkar
Publication year - 2013
Publication title -
north american journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2250-1541
pISSN - 1947-2714
DOI - 10.4103/1947-2714.109189
Subject(s) - colorectal cancer , cetuximab , medicine , genotype , allele , epidermal growth factor receptor , oncology , population , carcinogenesis , gastroenterology , cancer , immunology , genetics , gene , biology , environmental health
Colorectal cancer contributes heavily to cancer morbidity and mortality worldwide. Numerous therapies are currently in use, including monoclonal antibodies against cellular components involved in tumorigenesis such as epidermal growth factor receptors (EGFRs). Studies showed the polymorphism [R521K] GàA in the EGFR gene to be involved in both colorectal cancer susceptibility and clinical response to therapeutics (e.g., Cetuximab).