Magnetic resonance imaging in pantothenate kinase-2-associated neurodegeneration | Zendy

Paramdeep Singh | Zendy; Kavita Saggar | Zendy; Maneet Kaur | Zendy; DavinderSingh Pannu | Zendy

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Magnetic resonance imaging in pantothenate kinase-2-associated neurodegeneration

Author(s) -

Paramdeep Singh,

Kavita Saggar,

Maneet Kaur,

DavinderSingh Pannu

Publication year - 2012

Publication title -

journal of pediatric neurosciences

Language(s) - English

Resource type - Journals

eISSN - 1998-3948

pISSN - 1817-1745

DOI - 10.4103/1817-1745.97618

Subject(s) - globus pallidus , medicine , magnetic resonance imaging , neurodegeneration , dystonia , neuroscience , pathology , basal ganglia , central nervous system , disease , psychology , radiology , psychiatry

Pantothenate kinase-2-associated neurodegeneration (PKAN) is a rare autosomal recessive pediatric neurodegenerative disorder characterized by rigidity, dystonia, impaired postural reflexes, and progressive dementia. On T2-weighted magnetic resonance imaging images, marked low signal intensity is seen in the globus pallidus. This low signal intensity surrounds a central region of high signal intensity in the anteromedial globus pallidus, giving an eye-of-the-tiger appearance.

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