Open AccessHemispherotomy in an infant with hemimegalencephaly
Author(s) -
Shilpa Kulkarni,
Chandrashekhar Deopujari,
Varsha A. Patil,
Rafat Sayed
Publication year - 2015
Publication title -
journal of pediatric neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.247
H-Index - 18
eISSN - 1998-3948
pISSN - 1817-1745
DOI - 10.4103/1817-1745.159210
Subject(s) - hemimegalencephaly , medicine , disconnection , epilepsy , epilepsy surgery , pediatrics , encephalopathy , intervention (counseling) , psychiatry , cortical dysplasia , political science , law
Hemimegalencephaly (HME) is a rare hamartomatous congenital malformation of the brain. The epilepsy pattern in HME can be partial seizures or may present as spasms as in epileptic encephalopathy. Epilepsy associated with HME is usually resistant to antiepileptic drugs and requires surgical intervention. Hemispheric disconnection has been reported to be efficient in seizure control and prevents further cognitive injury and developmental delay. We report a case of HME, who underwent a two-stage hemispherotomy due to complications in the first surgery. She had more than 90% reduction of seizures with good developmental outcome on follow-up. Thus, despite risks of the procedure, early surgery should be preferred in infants with HME.