Open AccessInfantile Alexander disease: A rare leukodystrophy
Author(s) -
K. Jagadish Kumar,
Harish Kumar Suryaprakash,
V. G. Manjunath,
S Harsha
Publication year - 2012
Publication title -
journal of pediatric neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.247
H-Index - 18
eISSN - 1998-3948
pISSN - 1817-1745
DOI - 10.4103/1817-1745.102573
Subject(s) - macrocephaly , leukodystrophy , medicine , krabbe disease , magnetic resonance imaging , disease , pediatrics , pathology , radiology
Infantile Alexander disease (AD) is a rare leukodystrophy characterized by its early onset within 2 years of life and clinically presents with macrocephaly, seizures, and retarded psychomotor development. Magnetic resonance imaging (MRI) shows characteristic symmetric white matter abnormalities with frontal predominance. We present a case of infantile AD with typical clinical characteristics and MRI features.