Open AccessStudy of the association between −403G/A and −28C/G RANTES gene polymorphisms and asthma in Lebanon
Author(s) -
Rahas,
Hana Fakhoury,
Hania Nakkash Chmaisse,
Rajaa Makki
Publication year - 2012
Publication title -
annals of thoracic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.639
H-Index - 33
eISSN - 1817-1737
pISSN - 1998-3557
DOI - 10.4103/1817-1737.91558
Subject(s) - asthma , atopy , allele , genotype , immunology , chemokine , medicine , allele frequency , promoter , case control study , gene , genetics , biology , inflammation , gene expression
Asthma is a complex inflammatory condition often associated with bronchial hyper reactivity and atopy. Genetic and environmental factors are implicated in the etiopathogenesis of asthma. Regulated upon Activation Normal T- cell Expressed and Secreted (RANTES) is a CC chemokine responsible for the recruitment of inflammatory cells, suggesting a possible role for this chemokine in asthma. Both -403A and -28G alleles of the RANTES promoter region were found to be associated with asthma/atopy in some but not all studies.