Open AccessEffect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms
Author(s) -
Prashant Dalvi,
A. P. Singh,
Hiren R. Trivedi,
Feroz D Ghanchi,
Dinesh Parmar,
Suresh D Mistry
Publication year - 2011
Publication title -
annals of thoracic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.639
H-Index - 33
eISSN - 1817-1737
pISSN - 1998-3557
DOI - 10.4103/1817-1737.84777
Subject(s) - doxycycline , medicine , copd , gastroenterology , matrix metalloproteinase , antibiotics , proteolytic enzymes , enzyme , microbiology and biotechnology , biology , biochemistry , chemistry
The protease-antiprotease hypothesis proposes that inflammatory cells and oxidative stress in chronic obstructive pulmonary disease (COPD) produce increased levels of proteolytic enzymes (neutrophil elastase, matrix metalloproteinases [MMP]) which contribute to destruction of parenchyma resulting in progressive decline in forced expiratory volume in one second. Doxycycline, a tetracycline analogue, possesses anti-inflammatory properties and inhibits MMP enzymes.