Open AccessGood outcomes with the intraventricular vancomycin therapy in a patient with ruptured brain abscesses
Author(s) -
Ninh Doan,
Ha Son Nguyen,
Luyuan Li,
Saman Shabani,
Michael Gelsomino,
Vijay Johnson
Publication year - 2018
Publication title -
asian journal of neurosurgery
Language(s) - English
Resource type - Journals
ISSN - 2248-9614
DOI - 10.4103/1793-5482.185065
Subject(s) - medicine , vancomycin , refractory (planetary science) , antibiotics , brain abscess , intraventricular hemorrhage , surgery , systemic antibiotics , abscess , anesthesia , intensive care medicine , staphylococcus aureus , pregnancy , physics , biology , astrobiology , bacteria , gestational age , microbiology and biotechnology , genetics
Brain abscesses are associated with high morbidity and mortality rates. In particular, patients with intraventricular rupture of brain abscess (IVROBA) exhibit mortality rates up to 85%. Treatment options are lacking for IVROBA, once patients become refractory to intravenous antibiotics and surgical drainage. Limited data exist regarding the risks and benefits of intraventricular therapy in such a scenario. We report a patient with IVROBA, who deteriorated while on systemic antibiotics; once intraventricular vancomycin was employed, the patient demonstrated remarkable improvement without perceivable side effects. This case suggests that intraventricular vancomycin may be a safe, effective, and viable option for the treatment of IVROBA, especially for patients becoming refractory to systemic antibiotics.