Open AccessEvaluation of hyperglycaemic response to intra-operative dexamethasone administration in patients undergoing elective intracranial surgery: A randomised, prospective study
Author(s) -
Rakesh Sethi,
Imtiaz A Naqash,
Sukhminder Jit Singh Bajwa,
Vikas Dutta,
Altaf Ramzan,
Syed Amir Zahoor
Publication year - 2016
Publication title -
asian journal of neurosurgery
Language(s) - English
Resource type - Journals
ISSN - 2248-9614
DOI - 10.4103/1793-5482.177660
Subject(s) - medicine , dexamethasone , anesthesia , bolus (digestion) , placebo , corticosteroid , analysis of variance , elective surgery , prospective cohort study , saline , surgery , alternative medicine , pathology
The glucocorticoid dexamethasone in a bolus dose of 8-10 mg followed by quarterly dose of 4 mg is commonly used during intracranial surgery so as to reduce oedema and vascular permeability. However, the detrimental hyperglycaemic effects of dexamethasone may override its potentially beneficial effects. The present prospective, randomised study aimed at comparing the degree and magnitude of hyperglycaemia induced by prophylactic administration of dexamethasone in patients undergoing elective craniotomy.