Open AccessA case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry
Author(s) -
Shinichi Nakatsuka,
Isao Tanaka,
Tadasuke Nagatomo,
Michiaki Yamane,
Kenji Sugio,
Ryuichi Yoshino,
Kazuko Oku,
Teruaki Nagano,
Hayato Kimura,
Kazuya Nakajo,
Gaku Kawabata
Publication year - 2012
Publication title -
cyto journal/cytojournal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.371
H-Index - 27
eISSN - 0974-5963
pISSN - 1742-6413
DOI - 10.4103/1742-6413.95528
Subject(s) - medicine , urethral diverticulum , cystoscopy , adenocarcinoma , clear cell adenocarcinoma , papillary tumor , pathology , urethra , biopsy , immunohistochemistry , cytology , urinary system , urology , clear cell , cancer , anatomy
Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the urethra and cystourethroscopy showed papillary and villous tumors in the urethral diverticula. Cytology of the urine sediment showed papillary or spherical clusters of atypical cells, some of which had clear abundant cytoplasm and formed mirror ball-like clusters, suggesting adenocarcinoma. Although histological diagnosis was indeterminate by biopsy and transurethral resection (TUR) because of absence of stromal invasion, surgically resected specimen via cysturethrectomy revealed that the tumor was clear cell carcinoma. Urinary cytological findings and immunohistochemical analysis for CD15, Ki-67, and p53 might be useful for accurate diagnosis of clear cell adenocarcinoma that arises from the urethral diverticulum when sufficient materials are not available by biopsy and TUR