Open AccessInvestigation of the relationship between miR-33a, miR-122, erythrocyte membrane fatty acids profile, and serum lipids with components of metabolic syndrome in type 2 diabetic patients
Author(s) -
Fatemeh Masoudi,
Mohammadreza Sharifi,
Morteza Pourfarzam
Publication year - 2022
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.343078
Subject(s) - endocrinology , medicine , insulin resistance , polyunsaturated fatty acid , metabolic syndrome , microrna , type 2 diabetes , mir 122 , fatty acid , type 2 diabetes mellitus , glucose homeostasis , lipid metabolism , population , cholesterol , metabolism , lipid profile , fatty acid metabolism , diabetes mellitus , biology , biochemistry , gene , environmental health
MicroRNAs (miRNAs) are small non-coding RNA molecules acting as critical regulators of post-transcriptional gene expression. MiR-33a and miR-122 have a crucial role in cholesterol and lipid metabolism. Therefore, their dysregulation may contribute to metabolic abnormality and their inhibition may be a useful therapeutic strategy. The objective of the present study was to investigate the relationship between miR-33a, miR-122, erythrocyte membrane fatty acids profile, and serum lipids with components of metabolic syndrome in an Iranian population suffering from type 2 diabetes mellitus (T2DM).