Open AccessThymoquinone abrogates methamphetamine-induced striatal neurotoxicity and hyperlocomotor activity in mice
Author(s) -
Ali Roohbakhsh,
Mohammad Moshiri,
Azam Salehi Kakhki,
Milad Iranshahy,
Faisal Mohammad Amin,
Leila Etemad
Publication year - 2021
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.319577
Subject(s) - thymoquinone , meth , methamphetamine , neurotoxicity , pharmacology , neuroprotection , open field , antioxidant , superoxide dismutase , chemistry , medicine , toxicity , biochemistry , monomer , organic chemistry , acrylate , polymer
Methamphetamine (METH) abuse has devastating consequences on the nervous system. There are limited therapy choices in METH abuse with reduced effectiveness and elevated recurrence rates. Thymoquinone (TQ), the most bioactive constituent of Nigella sativa seeds exerts neuroprotective effects mainly via antioxidant properties. This study aimed to evaluate the effect of TQ against METH-induced striatal neurotoxicity and hyperlocomotor activity in mice.