Open AccessSuppression of hypoxia and inflammatory pathways by Phyllanthus niruri extract inhibits angiogenesis in DMBA-induced breast cancer mice
Author(s) -
Abu Hanifah Ramadhani,
Ahmad Hafidul Ahkam,
Aditya Ragil Suharto,
Yoga Dwi Jatmiko,
Hideo Tsuboi,
Muhaimin Rifa’i
Publication year - 2021
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.310528
Subject(s) - angiogenesis , cd31 , dmba , vascular endothelial growth factor , neovascularization , immunohistochemistry , cancer research , carcinogenesis , chemistry , medicine , immunology , cancer , vegf receptors
Angiogenesis has been one of the hallmarks of cancer. In recent years, Phyllanthus niruri extract (PNE) was reported to inhibit angiogenesis by decreasing the levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) in breast cancer. However, the experimental results were confirmed in cancer cell lines only, whereas the anti-angiogenic activity in animal models has not been demonstrated. In this study, we tried to examine the anti-angiogenic activity of PNE on BALB/c strain mice models that were induced for breast cancer using the carcinogenic substance 7,12- dimethylbenz[a]anthracene (DMBA).