Open AccessHarmine protects mercuric chloride kidney-induced injury by antioxidant activity in male mice: a biochemical and histological study
Author(s) -
Cyrus Jalili,
Nasim Akhshi,
Iraj Rashidi,
Ali Ghanbari
Publication year - 2020
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.301339
Subject(s) - chemistry , nephrotoxicity , creatinine , kidney , antioxidant , pharmacology , oxidative stress , glutathione , blood urea nitrogen , renal function , endocrinology , biochemistry , toxicity , enzyme , medicine , organic chemistry
Mercuric chloride (Merc) can cause kidney toxicity. Harmine (Harm), an herbal alkaloid has various pharmacological and medicinal effects mainly because of its antioxidant activity. In this study, therefore, Harm's protective mechanisms on Merc-induced nephrotoxicity in BALB/c male mice were investigated.