Open AccessAnti-Toxoplasma gondii activity of 5-oxo-hexahydroquinoline derivatives: synthesis, in vitro and in vivo evaluations, and molecular docking analysis
Author(s) -
Mohammadsaeid Zahedi,
Qasem Asgari,
Fatemeh Badakhshan,
Amirhossein Sakhteman,
Sara Ranjbar,
Mahsima Khoshneviszadeh
Publication year - 2020
Publication title -
research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 29
eISSN - 1735-9414
pISSN - 1735-5362
DOI - 10.4103/1735-5362.293515
Subject(s) - toxoplasma gondii , in vivo , docking (animal) , in vitro , autodock , enzyme , propidium iodide , flow cytometry , chemistry , active site , pharmacology , biochemistry , stereochemistry , biology , microbiology and biotechnology , in silico , programmed cell death , immunology , apoptosis , medicine , nursing , gene , antibody
The aim of this study was to evaluate the in vitro and in vivo anti- Toxoplasma gondii ( T. gondii ) effect of 5-oxo-hexahydroquinoline compounds. Moreover, molecular docking study of the compounds into the active site of enoyl-acyl carrier protein reductase (ENR) as a necessary enzyme for the vitality of apicoplast was carried out.