Open AccessAssociation between serotonin transporter gene polymorphism and recurrent aphthous stomatitis
Author(s) -
Aastha Manchanda,
Asha R Iyengar,
Seema Patil
Publication year - 2016
Publication title -
dental research journal.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.334
H-Index - 17
eISSN - 2008-0255
pISSN - 1735-3327
DOI - 10.4103/1735-3327.182149
Subject(s) - recurrent aphthous stomatitis , serotonin transporter , genotype , allele , stomatitis , gene , biology , polymorphism (computer science) , polymerase chain reaction , genetics , gene polymorphism , anxiety , medicine , gastroenterology , psychiatry
Anxiety-related traits have been attributed to sequence variability in the genes coding for serotonin transmission in the brain. Two alleles, termed long (L) and short (S) differing by 44 base pairs, are found in a polymorphism identified in the promoter region of serotonin transporter gene. The presence of the short allele and SS and LS genotypes is found to be associated with the reduced expression of this gene decreasing the uptake of serotonin in the brain leading to various anxiety-related traits. Recurrent aphthous stomatitis (RAS) is an oral mucosal disease with varied etiology including the presence of stress, anxiety, and genetic influences. The present study aimed to determine this serotonin transporter gene polymorphism in patients with RAS and compare it with normal individuals.