Open AccessPolyphenols as potential enhancers of stem cell therapy against neurodegeneration
Author(s) -
Diana Rodríguez-Vera,
Antonio Abad-García,
Nancy Vargas-Mendoza,
Rodolfo PintoAlmazán,
Eunice D. FarfánGarcía,
Ángel Morales-González,
Marvin A. SorianoUrsúa
Publication year - 2022
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.335826
Subject(s) - neurodegeneration , polyphenol , limiting , medicine , pharmacology , stem cell , neuroscience , bioinformatics , biology , disease , antioxidant , biochemistry , microbiology and biotechnology , pathology , mechanical engineering , engineering
The potential of polyphenols for treating chronic-degenerative diseases (particularly neurodegenerative diseases) is attractive. However, the selection of the best polyphenol for each treatment, the mechanisms by which they act, and their efficacy are frequently discussed. In this review, the basics and the advances in the field, as well as suggestions for using natural and synthetic polyphenols alone or in a combinatorial strategy with stem cell assays, are compiled and discussed. Thus, stem cells exhibit several responses when polyphenols are added to their environment, which could provide us with knowledge for advancing the elucidation of the origin of neurodegeneration. But also, polyphenols are being included in the innovative strategies of novel therapies for treating neurodegenerative diseases as well as metabolic diseases related to neurodegeneration. In this regard, flavonoid compounds are suggested as the best natural polyphenols due to their several mechanisms for acting in ameliorative effects; but increasing reports are involving other polyphenols. Even if some facts limiting bioactivity prevent them from conventional use, some natural polyphenols and derivatives hold the promise for being improved compounds, judged by their induced effects. The current results suggest polyphenols as enhancers of stem cell therapy against the targeted diseases.