Open AccessTowards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain
Author(s) -
Joel F. Ritala,
Seán B. Lyne,
Antti Sajanti,
Romuald Girard,
Janne Koskimäki
Publication year - 2022
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.314291
Subject(s) - neuroscience , neurotrophin , neuroregeneration , neuroplasticity , amyotrophic lateral sclerosis , low affinity nerve growth factor receptor , neurotrophic factors , biology , regeneration (biology) , disease , medicine , receptor , central nervous system , pathology , microbiology and biotechnology , biochemistry
The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses, modify the response to injury, and alter the adaptation response. Intriguingly, the prior studies highlight the role of p75 neurotrophin receptor (p75 NTR ) in various injuries and diseases such as central nervous system injuries, Alzheimer's disease and amyotrophic lateral sclerosis. More comprehensive elucidation of the mechanisms, and therapies targeting these molecular signaling networks may allow for neuronal tissue regeneration following an injury. Due to a diverse role of the p75 NTR in biology, the body of evidence comprising its biological role is diffusely spread out over numerous fields. This review condenses the main evidence of p75 NTR for clinical applications and presents new findings from published literature how data mining approach combined with bioinformatic analyses can be utilized to gain new hypotheses in a molecular and network level.