Open AccessAnimal models used to study direct peripheral nerve repair: a systematic review
Author(s) -
Francisco Javier Vela,
Guadalupe Martínez-Chacón,
Alberto Ballestín,
Jose Campos,
Francisco M. SánchezMargallo,
E. Doménech Abellán
Publication year - 2020
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.266068
Subject(s) - medicine , forelimb , regeneration (biology) , peripheral nerve , peripheral nerve injury , nerve repair , animal model , nerve injury , surgery , physical medicine and rehabilitation , anatomy , biology , microbiology and biotechnology
Peripheral nerve repair is required after traumatic injury. This common condition represents a major public health problem worldwide. Recovery after nerve repair depends on several factors, including the severity of the injury, the nerve involved, and the surgeon's technical skills. Despite the precise microsurgical repair of nerve lesions, adequate functional recovery is not always achieved and, therefore, the regeneration process and surgical techniques are still being studied. Pre-clinical animal models are essential for this research and, for this reason, the focus of the present systematic review (according to the PRISMA statement) was to analyze the different animal models used in pre-clinical peripheral nerve repair studies.