Open AccessDietary habits, lifestyle factors and neurodegenerative diseases
Author(s) -
Aurel PopaWagner,
Dinu Iuliu Dumitraşcu,
Bogdan Capitanescu,
Eugen Bogdan Petcu,
Roxana Surugiu,
WenHui Fang,
Danut-Adrian Dumbrava
Publication year - 2020
Publication title -
neural regeneration research/neural regeneration research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.266045
Subject(s) - medicine , mediterranean diet , context (archaeology) , oxidative stress , polyunsaturated fatty acid , ageing , neurogenesis , aging brain , cognitive decline , gerontology , dementia , biology , neuroscience , fatty acid , disease , paleontology , biochemistry
Worldwide stroke is increasing in parallel with modernization, changes in lifestyle, and the growing elderly population. Our review is focused on the link between diet, as part of 'modern lifestyle', and health in the context of genetic predisposition of individuals to 'unhealthy' metabolic pathway activity. It is concluded that lifestyle including high sugar diets, alcohol and tobacco addiction or high fat diets as well as ageing, brain injury, oxidative stress and neuroinflammation, negatively influence the onset, severity and duration of neurodegenerative diseases. Fortunately, there are several healthy dietary components such as polyunsaturated fatty acids and the anti-oxidants curcumin, resveratrol, blueberry polyphenols, sulphoraphane, salvionic acid as well as caloric restriction and physical activity, which may counteract ageing and associated neurodegenerative diseases via increased autophagy or increased neurogenesis in the adult brain.