Open AccessDiabetic neuropathy research: from mouse models to targets for treatment
Author(s) -
Vuong Minh Pham,
Shinji Matsumura,
Tayo Katano,
Nobuo Funatsu,
Seiji Ito
Publication year - 2019
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.259603
Subject(s) - medicine , diabetic neuropathy , diabetes mellitus , peripheral neuropathy , mechanism (biology) , neurotrophic factors , intensive care medicine , bioinformatics , neuroscience , endocrinology , psychology , biology , philosophy , receptor , epistemology
Diabetic neuropathy is one of the most serious complications of diabetes, and its increase shows no sign of stopping. Furthermore, current clinical treatments do not yet approach the best effectiveness. Thus, the development of better strategies for treating diabetic neuropathy is an urgent matter. In this review, we first discuss the advantages and disadvantages of some major mouse models of diabetic neuropathy and then address the targets for mechanism-based treatment that have been studied. We also introduce our studies on each part. Using stem cells as a source of neurotrophic factors to target extrinsic factors of diabetic neuropathy, we found that they present a promising treatment.