Open AccessSodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression
Author(s) -
Hae June Lee,
Yeonghoon Son,
Minyoung Lee,
Changjong Moon,
Sung Hoon Kim,
In Sik Shin,
Miyoung Yang,
Sangwoo Bae,
Joong Sun Kim
Publication year - 2019
Publication title -
neural regeneration research/neural regeneration research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.255974
Subject(s) - sodium butyrate , creb , neurotrophic factors , doublecortin , hippocampal formation , brain derived neurotrophic factor , neurogenesis , endocrinology , medicine , neun , neuroscience , hippocampus , pharmacology , chemistry , biology , dentate gyrus , biochemistry , immunohistochemistry , receptor , transcription factor , gene
Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages. To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments, adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation. Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation. We also detected the expression levels of neurogenic cell markers (doublecortin) and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor. Radiation-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. Sodium butyrate pretreatment reversed these changes. These findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences (approval No. KIRAMS16-0002) on December 30, 2016.