Open AccessMemory consolidation during sleep and adult hippocampal neurogenesis
Author(s) -
Iyo Koyanagi,
Katherine G. Akers,
Pablo Vergara,
Sakthivel Srinivasan,
Takeshi Sakurai,
Masanori Sakaguchi
Publication year - 2019
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.243695
Subject(s) - neurogenesis , neuroscience , dentate gyrus , neural stem cell , hippocampal formation , progenitor cell , memory consolidation , stem cell , hippocampus , psychology , biology , medicine , genetics
In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarifying the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review.