Open AccessCurrent surgical treatments for Parkinson's disease and potential therapeutic targets
Author(s) -
Darrin J. Lee,
Robert F. Dallapiazza,
Philippe De Vloo,
Andrés M. Lozano
Publication year - 2018
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.235220
Subject(s) - deep brain stimulation , medicine , parkinson's disease , disease , resting tremor , radiosurgery , essential tremor , physical medicine and rehabilitation , neuroscience , surgery , psychology , radiation therapy , pathology
Currently, the most common surgical treatment for Parkinson's disease is deep brain stimulation (DBS). This treatment strategy is typically reserved for bradykinesia, rigidity and tremor in patients who no longer respond to medication in a predictable manner or who suffer medication-induced dyskinesias. In addition to DBS, ablative procedures like radiofrequency, radiosurgery and focused ultrasound are also utilized for select tremor symptoms. In this review, we discuss evolving surgical techniques, targets, and emerging technology. In addition, we evaluate potential paradigm shifts in treatment, including gene therapy, immunotherapy and cell transplantation. While these new techniques and treatment options are still in their infancy, advances in Parkinson's disease treatment are rapidly expanding.