Open AccessExtract of Ginkgo biloba promotes neuronal regeneration in the hippocampus after exposure to acrylamide
Author(s) -
Weiling Huang,
Yuxin Ma,
Yu Fan,
Sheng-min Lai,
Hongqing Liu,
Jing Liu,
Li Luo,
Guoying Liu,
Sumin Tian
Publication year - 2017
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.213548
Subject(s) - ginkgo biloba , doublecortin , neurotoxicity , neuroprotection , acrylamide , pharmacology , hippocampus , ginkgo , medicine , chemistry , traditional medicine , toxicity , dentate gyrus , organic chemistry , copolymer , polymer
Previous studies have demonstrated a neuroprotective effect of extract of Ginkgo biloba against neuronal damage, but have mainly focused on antioxidation of extract of Ginkgo biloba . To date, limited studies have determined whether extrasct of Ginkgo biloba has a protective effect on neuronal damage. In the present study, acrylamide and 30, 60, and 120 mg/kg extract of Ginkgo biloba were administered for 4 weeks by gavage to establish mouse models. Our results showed that 30, 60, and 120 mg/kg extract of Ginkgo biloba effectively alleviated the abnormal gait of poisoned mice, and up-regulated protein expression levels of doublecortin (DCX), brain-derived neurotrophic factor, and growth associated protein-43 (GAP-43) in the hippocampus. Simultaneously, DCX- and GAP-43-immunoreactive cells increased. These findings suggest that extract of Ginkgo biloba can mitigate neurotoxicity induced by acrylamide, and thereby promote neuronal regeneration in the hippocampus of acrylamide-treated mice.