Open AccessApelin-13 as a novel target for intervention in secondary injury after traumatic brain injury
Author(s) -
Haijun Bao,
Qiu Hai-yang,
Jinxia Kuai,
Chengjie Song,
Shaoxian Wang,
Chaoqun Wang,
Hua-bin Peng,
Wen Bo Han,
Yongping Wu
Publication year - 2016
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.187049
Subject(s) - apelin , traumatic brain injury , neuroprotection , medicine , hippocampus , central nervous system , aquaporin 4 , pharmacology , ischemia , cortex (anatomy) , blood–brain barrier , cerebral edema , cerebral cortex , anesthesia , neuroscience , biology , receptor , psychiatry
The adipocytokine, apelin-13, is an abundantly expressed peptide in the nervous system. Apelin-13 protects the brain against ischemia/reperfusion injury and attenuates traumatic brain injury by suppressing autophagy. However, secondary apelin-13 effects on traumatic brain injury-induced neural cell death and blood-brain barrier integrity are still not clear. Here, we found that apelin-13 significantly decreases cerebral water content, mitigates blood-brain barrier destruction, reduces aquaporin-4 expression, diminishes caspase-3 and Bax expression in the cerebral cortex and hippocampus, and reduces apoptosis. These results show that apelin-13 attenuates secondary injury after traumatic brain injury and exerts a neuroprotective effect.