Open AccessBridging peripheral nerves using a deacetyl chitin conduit combined with short-term electrical stimulation
Author(s) -
Zhongli Zhang,
Xin Li,
Zuo Songjie,
Jie Xiao,
Peixun Zhang
Publication year - 2014
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.133168
Subject(s) - stimulation , axon , peripheral , electrical conduit , bridging (networking) , biomedical engineering , sciatic nerve , chitin , regeneration (biology) , nerve conduction velocity , anatomy , peripheral nervous system , peripheral nerve , materials science , medicine , chemistry , neuroscience , biology , central nervous system , microbiology and biotechnology , chitosan , computer science , telecommunications , computer network , biochemistry
Previous studies have demonstrated that deacetyl chitin conduit nerve bridging or electrical stimulation can effectively promote the regeneration of the injured peripheral nerve. We hypothesized that the combination of these two approaches could result in enhanced regeneration. Rats with right sciatic nerve injury were subjected to deacetyl chitin conduit bridging combined with electrical stimulation (0.1 ms, 3 V, 20 Hz, for 1 hour). At 6 and 12 weeks after treatment, nerve conduction velocity, myelinated axon number, fiber diameter, axon diameter and the thickness of the myelin sheath in the stimulation group were better than in the non-stimulation group. The results indicate that deacetyl chitin conduit bridging combined with temporary electrical stimulation can promote peripheral nerve repair.