Open AccessRapamycin promotes Schwann cell migration and nerve growth factor secretion
Author(s) -
Fang Liu,
Haiwei Zhang,
Kaiming Zhang,
Xinyu Wang,
Shipu Li,
Yi Yin
Publication year - 2014
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.130101
Subject(s) - schwann cell , regeneration (biology) , microbiology and biotechnology , peripheral nerve , nerve guidance conduit , cell growth , secretion , nerve growth factor , in vitro , downregulation and upregulation , chemistry , peripheral nerve injury , cell , neuroscience , biology , anatomy , endocrinology , biochemistry , receptor , gene
Rapamycin, similar to FK506, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the effects of different concentrations of rapamycin and FK506 on Schwann cells and investigated effects and mechanisms of rapamycin on improving peripheral nerve regeneration. Results demonstrated that the lowest rapamycin concentration (1.53 nmol/L) more significantly promoted Schwann cell migration than the highest FK506 concentration (100μmol/L). Rapamycin promoted the secretion of nerve growth factors and upregulated growth-associated protein 43 expression in Schwann cells, but did not significantly affect Schwann cell proliferation. Therefore, rapamycin has potential application in peripheral nerve regeneration therapy.