Open AccessNormalization of ventral tegmental area structure following acupuncture in a rat model of heroin relapse
Author(s) -
Rongjun Zhang,
Xing-Hui Cai,
Xiaojing Song,
Chao-Yang Dong,
Xiaorong Hou,
Lei Lv
Publication year - 2014
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.128228
Subject(s) - ventral tegmental area , neurotrophic factors , brain derived neurotrophic factor , medicine , acupuncture , heroin , neuroscience , pharmacology , pathology , psychology , drug , dopamine , receptor , alternative medicine , dopaminergic
Drugs can cause obvious damage to the brain. To verify the relationship between acupuncture, neurotrophic factor expression and brain cell structural changes, this study established a rat model of heroin relapse using intramuscular injection of increasing amounts of heroin. During the detoxification period, rat models received acupuncture at Baihui (DU20) and Dazhui (DU14). Electron microscopy demonstrated that the structure of the ventral tegmental area in heroin relapse rats gradually became normalized after acupuncture treatment. Immunohistochemical staining exhibited that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor increased in the ventral tegmental area following acupuncture. Moreover, the effects were similar to that of methadone, a type of medicine called an opioid. Results suggested that acupuncture at Baihui and Dazhui protected brain neurons against injury in rats with heroin relapse by promoting brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression.