Open AccessSugammadex to reverse neuromuscular blockade and provide optimal conditions for motor-evoked potential monitoring
Author(s) -
Mehdi Trifa,
Senthil G. Krishna,
Ajay D’Mello,
Mohammed Hakim,
Joseph D. Tobias
Publication year - 2017
Publication title -
saudi journal of anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.416
H-Index - 24
eISSN - 1658-354X
pISSN - 0975-3125
DOI - 10.4103/1658-354x.203024
Subject(s) - sugammadex , neuromuscular blockade , rocuronium , medicine , anesthesia , neuromuscular monitoring , neuromuscular junction , dosing , pharmacology , neuroscience , propofol , biology
Sugammadex is a novel pharmacologic agent, which reverses neuromuscular blockade (NMB) via a mechanism that differs completely from acetylcholinesterase inhibitors. By encapsulating rocuronium, sugammadex can provide recovery of neuromuscular function even when there is a profound degree of NMB. We report anecdotal experience with the use of sugammadex to reverse NMB to facilitate intraoperative neurophysiological monitoring (motor evoked potentials) in an adolescent with scoliosis during posterior spinal fusion. Its potential application in this unique clinical scenario is discussed, and potential dosing schemes are reviewed.