Open Accessp53 and regulation of tumor metabolism
Author(s) -
Peng Jiang,
Wenjing Du,
Xiaolu Yang
Publication year - 2013
Publication title -
journal of carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.771
H-Index - 38
eISSN - 0974-6773
pISSN - 1477-3163
DOI - 10.4103/1477-3163.122760
Subject(s) - senescence , regulator , suppressor , master regulator , function (biology) , cancer research , mechanism (biology) , cellular senescence , p53 protein , cancer , biology , microbiology and biotechnology , medicine , bioinformatics , transcription factor , gene , genetics , phenotype , philosophy , epistemology
The tumor suppressor p53 plays a pre-eminent role in protecting against cancer, through its ability to sense various stresses and in turn invoke anti-proliferative and repair responses. Emerging evidence suggest that p53 is both a central sentinel for metabolic stresses and a master regulator of metabolic fluxes. This newly identified function of p53, along with the ability of p53 to induce senescence, appears to be crucial for the prevention of oncogenic transformation. A better understanding of the reciprocal regulation of p53 and metabolism, as well as p53-mediated connection between metabolism and senescence, may lead to the identification of valuable targets for tumor therapy