Open AccessExposure to industrial wideband noise increases connective tissue in the rat liver
Author(s) -
Maria João Oliveira,
Diamantino Freitas,
António Oliveira de Carvalho,
Laura Guimarães,
Ana Pinto,
Artur P. Águas
Publication year - 2012
Publication title -
noise and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.344
H-Index - 48
eISSN - 1998-4030
pISSN - 1463-1741
DOI - 10.4103/1463-1741.102959
Subject(s) - connective tissue , noise (video) , liver tissue , pathology , biology , medicine , anatomy , computer science , artificial intelligence , image (mathematics)
Rats were daily exposed (eight hours/day) for a period of four weeks to the same high-intensity wideband noise that was recorded before in a large textile plant. Histologic observation of liver sections of the rats was used to perform quantitative comparison of hepatic connective tissue (dyed by Masson trichromic staining) between the noise-exposed and control animals. For that, we have photographed at random centrolobular areas of stained rat liver sections. We found that noise exposure resulted in significant enhancement in the area of collagen-rich connective tissue present in the centrolobular domain of the rat liver. Our data strengthen previous evidence showing that fibrotic transformation is a systemic effect of chronic exposure of rodents and humans to industrial wideband noise.