Open AccessRegional liver disorder with differences in the accumulation of 99mTc-phytate and 99mTc-galactosyl human serum albumin
Author(s) -
Kohei Kotani,
Joji Kawabe,
Shigeki Higashiyama,
Susumu Shiomi
Publication year - 2017
Publication title -
world journal of nuclear medicine
Language(s) - English
Resource type - Journals
eISSN - 1607-3312
pISSN - 1450-1147
DOI - 10.4103/1450-1147.215493
Subject(s) - medicine , albumin , acute hepatitis , lobe , hepatitis , liver biopsy , left lobe , human serum albumin , serum albumin , viral hepatitis , necrosis , homogeneous , gastroenterology , pathology , biopsy , biochemistry , biology , physics , thermodynamics
We report a 56-year-old woman with regional liver disorder due to acute hepatitis. Computed tomographic images showed low signal density at a plain phase and prolonged contrast effect at a late phase in the left hepatic lobe, in which an accumulation of 99m Tc-phytate increased, whereas that of 99m Tc-galactosyl human serum albumin (GSA) decreased. Meanwhile, in the right lobe, an accumulation of 99m Tc-GSA showed more increased than that of 99m Tc-phytate. Liver biopsy showed massive hepatocyte necrosis and interface hepatitis in the left lobe, and moderate hepatitis in the right lobe. Differences in the accumulation between these scintigrams were helpful for understanding rapid necrosis in the left lobe, resulting in a compensatory enlargement of the right lobe. Clinicians should be aware that some cases of acute hepatitis cause regional liver disorder although most cases show homogeneous inflammation.