Open AccessIncreased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: Effect of treatment
Author(s) -
Soundravally Rajendiran,
Zachariah Bobby,
Abdoul Hamide
Publication year - 2012
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.98430
Subject(s) - medicine , ferritin , helicobacter pylori , hemoglobin , antioxidant , protein carbonylation , gastroenterology , ferrous , iron deficiency anemia , anemia , immunology , oxidative stress , lipid peroxidation , biochemistry , chemistry , organic chemistry
Collective evidences suggest the causal association of Helicobacter pylori infection with iron deficiency anemia. Generation of free radicals against this bacterium can lead to turbulence in oxidative-antioxidative system. This study was undertaken to evaluate the marker of oxidative protein injury, protein carbonylation, and total antioxidant status in anemic H. pylori-infected patients and to observe the alteration in them after treatment for 1 month with oral ferrous sulfate and anti-H. pylori therapy. Twenty anemic H. pylori-infected patients were randomly divided into 2 groups. The H. pylori-infected patients in Group I received both iron supplementation and anti-H pylori therapy, whereas patients in Group II received only the iron supplementation. Fifteen healthy volunteers served as controls. All the study parameters were estimated after 1 month of the treatment.