Open AccessConcurrent autoimmune hepatitis and grave′s disease in Hepatitis C during pegylated Interferon α-2a and ribavirin therapy
Author(s) -
Guru Trikudanathan,
Imad Ahmad,
Jonathan Israel
Publication year - 2011
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.84494
Subject(s) - ribavirin , medicine , autoimmune hepatitis , pegylated interferon , liver biopsy , immunology , interferon , liver disease , hepatitis c virus , hepatitis , antibody , hepatitis c , gastroenterology , virus , biopsy
Classical interferon-α has been shown to be associated with the development of a variety of autoimmune disorders. A 34-year-old white woman with chronic hepatitis C virus infection who was treated with pegylated interferon α-2a and ribavirin, developed Grave's disease and autoimmune hepatitis (AIH) at 32 and 44 weeks, respectively, following initiation of the therapy. The diagnosis of AIH was made based on the new development of anti-smooth muscle antibodies, anti-mitochondrial antibodies, and liver biopsy findings. It was confirmed by positive response to steroid challenge and was assessed according to the international AIH scoring system. Based on the previous case reports, we review the existing literature. Clinicians should be aware of the possibility of multiple autoimmune disorders during interferon-based therapy for chronic hepatitis.