Molecular gate keepers succumb to gene aberrations in colorectal cancer in Kashmiri population, revealing a high incidence area | Zendy

MushtaqA Siddiqi | Zendy; Syed Sameer Aga | Zendy; Shakeel Ul Rehman | Zendy; ArshadA Pandith | Zendy; Nidda Syeed | Zendy; Zafar A. Shah | Zendy; NissarA Chowdhri | Zendy; KhursheedA Wani | Zendy

Open Access

Molecular gate keepers succumb to gene aberrations in colorectal cancer in Kashmiri population, revealing a high incidence area

Author(s) -

MushtaqA Siddiqi,

Syed Sameer Aga,

Shakeel Ul Rehman,

ArshadA Pandith,

Nidda Syeed,

Zafar A. Shah,

NissarA Chowdhri,

KhursheedA Wani

Publication year - 2009

Publication title -

saudi journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.608

H-Index - 32

eISSN - 1998-4049

pISSN - 1319-3767

DOI - 10.4103/1319-3767.56102

Subject(s) - kashmiri , medicine , incidence (geometry) , colorectal cancer , population , gene , oncology , cancer research , cancer , genetics , environmental health , optics , biology , physics

Colorectal cancer (CRC) is one of the leading malignancies worldwide and has been reported to show geographical variation in its incidence, even within areas of ethnic homogeneity. The aim of this study was to identify p53 and K-ras gene mutations in CRC patients in a Kashmiri population, and to assess whether these mutations are linked with clinicopathological parameters.

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