Open AccessMolecular gate keepers succumb to gene aberrations in colorectal cancer in Kashmiri population, revealing a high incidence area
Author(s) -
Aga Syed Sameer,
Shakeel Ul Rehman,
Arshad A. Pandith,
Nidda Syeed,
Zaffar Amin Shah,
Nissar A. Chowdhri,
Khursheed Alam Wani,
Mushtaq A. Siddiqi
Publication year - 2009
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.56102
Subject(s) - transversion , missense mutation , genetics , colorectal cancer , single strand conformation polymorphism , gene , gene mutation , population , nonsense mutation , mutation , point mutation , biology , medicine , cancer , environmental health
Colorectal cancer (CRC) is one of the leading malignancies worldwide and has been reported to show geographical variation in its incidence, even within areas of ethnic homogeneity. The aim of this study was to identify p53 and K-ras gene mutations in CRC patients in a Kashmiri population, and to assess whether these mutations are linked with clinicopathological parameters.