Open AccessMicroRNA-155-enhanced autophagy in human gastric epithelial cell in response to Helicobacter pylori
Author(s) -
Kai Wu,
Chao-Hui Zhu,
Yi Yao,
Xin Wang,
Jiugang Song,
Junshan Zhai
Publication year - 2016
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.173756
Subject(s) - helicobacter pylori , autophagy , microrna , mir 155 , intracellular , ectopic expression , intestinal metaplasia , biology , immune system , medicine , cancer research , immunology , gene , microbiology and biotechnology , apoptosis , genetics
MicroRNAs (miRNAs) are a class of small noncoding RNAs acting as posttranscriptional gene expression regulators in many physiological and pathological conditions. MiR-155 is one kind of miRNAs that plays an important role in causing various diseases. However, the precise molecular mechanism of the ectopic expression of miR-155 in Helicobacter pylori infection remains poorly understood. Autophagy has recently been identified as an effective way to control the intracellular bacterium survival. In the present study, we demonstrate a novel role of miR-155 in regulating the autophagy-mediated anti-H. pylori response.