Open AccessBactericidal permeability increasing protein gene polymorphism is associated with inflammatory bowel diseases in the Turkish population
Author(s) -
Güray Can,
Hakan Akın,
Filiz Özdemir,
Hatice Can,
Bülent Yılmaz,
Fatih Eren,
Özlen Atuğ,
Belkıs Ünsal,
Hülya Över Hamzaoğlu
Publication year - 2015
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.161642
Subject(s) - ulcerative colitis , inflammatory bowel disease , turkish population , medicine , immunology , crohn's disease , intestinal permeability , gastroenterology , pathogenesis , genotype , gene polymorphism , disease , gene , biology , genetics
Inflammatory bowel disease, a chronic inflammatory disease with unknown etiology, affects the small and large bowel at different levels. It is increasingly considered that innate immune system may have a central position in the pathogenesis of the disease. As a part of the innate immune system, bactericidal permeability increasing protein has an important role in the recognition and neutralization of gram-negative bacteria. The aim of our study was to investigate the involvement of bactericidal permeability increasing protein gene polymorphism (bactericidal permeability increasing protein Lys216Glu) in inflammatory bowel disease in a large group of Turkish patients.