Open AccessPhospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley
Author(s) -
Manzoor Ahmad Malik,
Prabhat Kumar Srivastava,
Showkat Ali Zargar,
Balraj Mittal
Publication year - 2014
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.145330
Subject(s) - single nucleotide polymorphism , haplotype , medicine , odds ratio , genotype , logistic regression , genotyping , snp , oncology , carcinogenesis , gastroenterology , genetics , cancer , bioinformatics , gene , biology
Phospholipase C epsilon 1 (PLCE1) plays a crucial role in carcinogenesis and progression of several types of cancers. A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus. The aim of the present study was to investigate the role of three potentially functional SNPs (rs2274223A > G, rs3765524C > T, and rs7922612C > T) of PLCE1 in gastric cancer patients from Kashmir Valley.