Open AccessRole of interstitial collagenase gene promoter polymorphism in the etiology of gastric cancer
Author(s) -
Devulapalli Krishnaveni,
Amar Chand Bhayal,
Shravan Kumar Porike,
Ramanna Macherla,
A. Jyothy,
Pratibha Nallari,
Venkateshwari Ananthapur
Publication year - 2014
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.141693
Subject(s) - genotype , single nucleotide polymorphism , promoter , genotyping , medicine , microbiology and biotechnology , etiology , gastroenterology , genetics , gene , biology , gene expression
Gastric cancer (GC) is a multifactorial disorder mediated by genetic, epigenetic, and environmental risk factors. GC is the most common cancer in India and it is the third prominent cause of cancer death worldwide. A single nucleotide polymorphism (SNP) in the promoter region of interstitial collagenase (MMP-1) gene appears to have an impact on the transcriptional activity and regulation of its expression. Hence, the present study is aimed to evaluate the role of interstitial collagenase gene-1607 1G/2G (rs1799750) promoter polymorphism in the etiology of GC.