Open AccessOverexpression of cyclooxygenase-2 and transforming growth factor-beta 1 is an independent predictor of poor virological response to interferon therapy in chronic HCV genotype 4 patients
Author(s) -
Wafaey Gomaa,
Mohamed Ibrahim,
Mohamed E Shatat
Publication year - 2014
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.126324
Subject(s) - medicine , ribavirin , proportional hazards model , hepatitis c virus , interferon , fibrosis , hepatitis c , transforming growth factor , immunohistochemistry , stage (stratigraphy) , immunology , gastroenterology , virus , biology , paleontology
COX-2 and TGF-β1 are overexpressed in hepatitis C virus (HCV) infection and are related to hepatitis pathogenesis and hepatic fibrosis. The current study investigated the relationship between pretreatment COX-2 and TGF-β1 hepatic expression in HCV genotype 4 and the virological response to interferon therapy.