Open AccessStudy of non-organ-specific antibodies in children with Genotype 4 chronic Hepatitis C
Author(s) -
M. Kotb,
Naglaa Mohamed Kamal Alanani,
Laila M. Sherief,
Mohammed A Fouad,
Lamiaa A Elwahab,
Nermin Raafat
Publication year - 2013
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.121038
Subject(s) - medicine , genotype , antibody , autoantibody , immunology , hepatitis c virus , virology , virus , biology , gene , biochemistry
Adult studies established a relationship between hepatitis C virus (HCV) infection and the presence of non-organ-specific antibodies (NOSAs). Most studies were carried out on genotypes 1 and 2. Only a few studies addressed that issue in pediatrics. No studies have been carried out on autoimmunity and genotype 4 in children. We aim to investigate NOSAs in 80 Egyptian children with chronic HCV infection along with studying the underlying genotype of HCV, and correlating autoimmunity with the epidemiological, clinical, biochemical, and virological features.