Open AccessStudy of the cytoxin-associated gene a (CagA gene) in Helicobacter pylori using gastric biopsies of Iraqi patients
Author(s) -
Elham A. Kalaf,
Zahra M. Al-Khafaji,
Nahi Y Yassen,
Fadel A AL-Abbudi,
Saad N Sadwen
Publication year - 2013
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.108474
Subject(s) - caga , helicobacter pylori , pathogenesis , gene , genotyping , gastritis , biology , virulence , microbiology and biotechnology , genotype , medicine , genetics , immunology
The Helicobacter pylori CagA gene is a major virulence factor that plays an important role in gastric pathologies. The size variation of CagA gene, which is dependent on the 3' repeat region, contains one or more Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs and CagA multimerization (CM) motifs. Four segments flanking the EPIYA motifs, EPIYA -A, -B, -C, or -D, were reported to play a crucial role in the pathogenesis of H. pylori infection. The aim was to determine the roles of EPIYA segments and CM motifs in gastroduodenal pathogenesis in an Iraqi population.