Open AccessSplenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis
Author(s) -
Fares Tofailahmed Rajah,
Ali A.M. AlHabobi,
Noura Aloudah,
Ayumun I Osman,
Elwaleed Elhassan
Publication year - 2021
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.318532
Subject(s) - medicine , anti neutrophil cytoplasmic antibody , pathology , rapidly progressive glomerulonephritis , pulmonary hemorrhage , goodpasture syndrome , vasculitis , antibody , diffuse alveolar hemorrhage , glomerulonephritis , goodpasture's syndrome , glomerular basement membrane , kidney , disease , immunology , lung
Double-positive disease, defined by double-seropositivity for serum anti-glomerular basement membrane (GBM) antibodies and anti-neutrophil cytoplasmic antibodies (ANCA) is a rare cause of pulmonary-renal syndrome. Here, we present an exceptional course of a 20-year-old male with seropositivity for anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies and anti-GBM antibody, who presented first with renal impairment due to focal necrotizing crescentic glomerulonephritis. After receiving treatment, he presented two years later with a relapse manifesting with diffuse alveolar hemorrhage and multiple splenic infarcts. We discuss the clinical presentation patterns and treatment strategies of this entity.