Open AccessClinical and Histopathological Profile of Adolescent onset Idiopathic Nephrotic Syndrome in North Indian Children
Author(s) -
Kamal K. Kapoor,
Abhijeet Saha,
Nand Kishore Dubey,
V.K. Batra,
Ashish Upadhyay
Publication year - 2021
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.318525
Subject(s) - medicine , histopathology , nephrotic syndrome , incidence (geometry) , nephrology , minimal change disease , pediatrics , biopsy , disease , gastroenterology , pathology , glomerulonephritis , kidney , focal segmental glomerulosclerosis , physics , optics
Adolescent onset idiopathic nephrotic syndrome (INS) is marked by increased incidence atypical features and non-minimal change disease in histopathology. The objective of the study was to analyze the clinical features and histopathological spectrum of adolescent-onset INS. It was conducted in a Pediatric nephrology clinic of a tertiary care hospital in North India. We retrospectively evaluated clinical features, biochemical investigations and histopathology of 33 adolescents with idiopathic NS registered in pediatric nephrology clinic. Twenty-three (70.0%) adolescents had steroid resistant nephrotic syndrome. Hematuria was present in 39%, hypertension 36% and acute kidney injury (AKI) in 27%. Three-fourth of adolescents who underwent biopsy had non-minimal change disease in histopathology. Adolescent onset INS have increased incidence of AKI, hypertension, and non-minimal change disease.