Open AccessCoagulopathy in the nephrotic syndrome
Author(s) -
Sneha P Simon,
Jim Thomas
Publication year - 2020
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.284035
Subject(s) - medicine , coagulopathy , prothrombin time , nephrotic syndrome , partial thromboplastin time , disseminated intravascular coagulation , thromboplastin , hypoprothrombinemia , renal biopsy , gastroenterology , coagulation testing , abnormality , coagulation , consumptive coagulopathy , biopsy , vitamin k , psychiatry
Coagulopathy in the nephrotic syndrome (NS) is very rare. Simultaneous prolongation of both prothrombin time and activated partial thromboplastin time suggests common coagulation pathway abnormality such as liver dysfunction, Vitamin K deficiency, disseminated intravascular coagulation, or primary fibrinolysis. This results in difficulty in proceeding with renal biopsy and tissue diagnosis. We report one such case of NS with coagulopathy and refractoriness to correction with blood products, which led us to make a diagnosis of AL amyloidosis, which was confirmed with abdominal fat pad biopsy and other work-up.