Open AccessShort-course metronidazole-induced reversible acute neurotoxicity in a renal transplant recipient
Author(s) -
Pavitra Manu Dogra,
A. K. Bhatt,
Sanjay Kumar Agarwal,
Dipankar Bhowmik
Publication year - 2018
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.248315
Subject(s) - neurotoxicity , metronidazole , medicine , tacrolimus , diarrhea , gastroenterology , pharmacology , anesthesia , antibiotics , toxicity , transplantation , microbiology and biotechnology , biology
Neurotoxic manifestations due to chronic metronidazole intake are well known, but neurotoxicity due to short-term use of metronidazole is very rare. We present a case of acute neurotoxicity due to short course of injectable metronidazole given in usual doses to a renal allograft recipient for persistent diarrhea. It responded to withdrawal of the offending drug. Tacrolimus trough concentration did not increase during neurotoxicity, thereby ruling out any metronidazole-tacrolimus interaction. Magnetic resonance imaging of the brain showed widespread osmotic demyelination and its recovery after drug withdrawal. This is the first reported case of a renal transplant recipient developing acute neurotoxicity due to short-term use of metronidazole, without any increase in tacrolimus trough concentrations.