Open AccessBK Virus nephropathy in living donor renal allograft recipients: An observational study from a large transplant center in India
Author(s) -
Pallav Gupta,
Ashwani Gupta,
Anil Kumar Bhalla,
Manish Malik,
Anurag Gupta,
Vinant Bhargava,
Devinder Singh Rana
Publication year - 2018
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.248313
Subject(s) - medicine , interstitial nephritis , bk virus , immunosuppression , kidney , nephropathy , histopathology , urology , renal biopsy , biopsy , kidney transplantation , pathology , gastroenterology , endocrinology , diabetes mellitus
BK virus is a polyoma virus which remains in latent phase in the urinary tract, particularly in the renal tubular epithelial cells. In immunosuppressed patients, it is activated and manifests as tubule-interstitial nephritis causing renal allograft dysfunction. A total of 402 patients who underwent renal allograft biopsy from 2013 to 2016 were included in this study; six patients were diagnosed to have BK virus nephropathy. Histopathology showed ground glass intra-nuclear inclusions accompanied by acute tubular injury, interstitial inflammation, and varying degree of interstitial fibrosis and tubular atrophy. Patients were managed with reduction in the overall immunosuppression. Only one patient progressed to graft failure on follow-up. The overall prevalence of polyoma virus at our center is 1.49%.