Open AccessDistal renal tubular acidosis in sickle cell anemia
Author(s) -
Anjali Bharani,
Rani Manchanda,
Rajesh Kumar Singh,
Swati Prashant
Publication year - 2018
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.239637
Subject(s) - medicine , polyuria , hypokalemia , distal renal tubular acidosis , renal tubular acidosis , polydipsia , sickle cell anemia , metabolic acidosis , anemia , nephrocalcinosis , acidosis , gastroenterology , endocrinology , kidney , disease , diabetes mellitus
We report a rare case of two young male siblings with sickle cell anemia who presented with bilateral lower limb deformities, failure to thrive, polyuria, and polydipsia. On investigations, they were found to have normal anion gap metabolic acidosis, hypokalemia, and nephrocalcinosis were seen on ultrasonography of the kidneys. These reports were suggestive of distal renal tubular acidosis (dRTA). They were started on oral alkali replacement and potassium therapy with which clinical improvement was seen. Conventionally, renal tubular dysfunction is thought to occur infrequently in patients with sickle cell anemia. Hence, we report this rare association between sickle cell anemia and dRTA.